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Because the earth rotates on its axis, each day
has a period of light and a period of darkness; furthermore
as the axis of rotation is tilted, duration of daily period
of darkness and light vary during the course of the year.
Through evolution animals responded to those environmental
changes and have adapted to them through their biological
clock or circadian rhythms.
The circadian clock is actually one of the most
indispensable biological functions. The body responds not
only passively to external lighting conditions but also actively
by a circadian pacemaker which is written in the genes that
is synchronized with the cycles of the earth's rotation anticipating
the transition between day and night and triggering appropriate
changes in behavioral state and physiological activity. The
biological clock is therefore synchronized with the world
outside.
Circadian rhythm disorders can be created by intrinsic
factors (sleep disorders, aging, blindness, etc.) or extrinsic
factors (jet lag created by fast travel across several time
zones, shift-work). The effects of those disorders include
sleep depravation, fatigue, insomnia, disorientation, headache,
disturbed gastrointestinal function, cognitive deficits and
increased daytime fatigue. The production of several hormones
is affected by lag including growth hormone, ACTH, cortisol
and adrenalin.
Travel fatigue is often associated with jet lag.
The effects of travel fatigue are due to time spent in an environment
that is cramped and offers little opportunity for exercise, restricted
choice of food, dehydration due to dry cabin air and cabin hypoxia.
Jet lag has many symptoms. Traveling east you might
have trouble falling asleep at night. After traveling west
you might wake up too early in the morning. Those sleep problems
can make you feel tired, weak and clumsy. You might also have
trouble concentrating.
You can also have headaches and upset stomach.
Jet lag usually is worse for the first two days.
You are likely to get jet lag when you cross several
time zones in one day, usually after crossing at least 5 time
zones. For most people it is usually more difficult to go
east and it can get worse as you get older.
Shift workers also experience similar problems
and can benefit from the product.
PRS-Jet Lag is a natural food supplement for
travelers, made of natural extract from Opuntia ficus indica
(prickly pear cactus). The product is manufactured under GMP(Good
Manufacturing Practice) and submitted to vigorous quality
control. PRS-Jet Lag is not addictive.
Per capsule: Opuntia ficus indica (extracted using non-GMO corn oil) fish gelatin, glycerol, iron oxyde.
Each capsule contains 180 mg of Opuntia ficus indica extract.
In order to optimize the recovery from traveling, please follow these guidelines:
- Take PRS-Jet Lag at least 60 minutes before the beginning of the trip
- Do not take PRS-Jet Lag with a meal (take at least 1 hour before or 3 hours after a meal).
- Between 30 and 60 kg bw (66 to 132 lbs) = take 2 capsules
- Between 60 and 90 kg bw (132 to 198 lbs) = take 3 capsules and more than 90 kg (198 lbs) take 4 capsules
- The activity of PRS-Jet Lag lasts 72 hours.
Keep this product out of the reach of children.
Before using PRS-Jet Lag, contact a health professional if
you are taking a prescription medicine, are pregnant or nursing
or if you have any medical conditions.
Do not use PRS-Jet Lag if you have a known allergy to one
of the ingredients.
Do not use after expiration date. Keep at room temperature.
Prolonged exposure to light and heat may damage the product.
Use a food supplement with well-balanced nutrition. No side
effects have been reported following the suggested use of
the product.
The statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose,
treat, cure or prevent any disease.
Heat shock proteins (Hsp) are a group of highly
conserved proteins present in the cells of all living organisms.
Hsp families include both constitutive and stress inducible
members whose primary function is to interact with naïve
and denatured proteins to prevent the aggregation of aberrantly
folded proteins, facilitate the folding of naïve proteins,
facilitate the refolding of denatured proteins to aid in the
cellular protein trafficking. They are classified according
to their molecular weight ranging from 8 to 110 kDa. Inducible
proteins are produced in response to external stress such
as physical activity and heat. Their role is to bind to proteins
during stress and facilitate their successful repair from
injury. The most inducible of the Hsp is Hsp72. Exercise and
other stresses have been demonstrated to increase Hsp72 in
a variety of tissues in several mammalian species.
Opuntia ficus indica known as the prickly
pear cactus grows in some of the hottest and most arid regions
of the world. It is common in deserts of North and South America,
Africa and the Mediterranean area. Because of its ability
to survive extremes of low and high temperatures and drought
the cactus likely possesses active molecules protecting cells
and restoring cell functions.
 Naturally
grown prickly pear cactus (Opuntia ficus indica) is collected
in a pollution-free area and processed under strict manufacturing
conditions. The extract is produced by drying the epicarp
and specific tissues of the fruit and by using a patented
extraction process. The biological activity is controlled
using standardized in vitro assay titration measuring the
quantity of Hsp72 produced by cells in culture after exposure
to heat stress (43 C for 15 min.) in the presence of the extract.
The extract can accelerate the production and release
of Hsp72 in humans and animals. The acceleration of the release
after stress by PRS-Jet Lag allows cells like the muscle cells
and the brain cells to withstand a metabolic insult that could
otherwise cause significant damage.
Sleep is homeostatically controlled. Studies have
shown that sleep depravation induces the expression of heat
stress proteins (HSP) indicating that sleep depravation is
a stress for the neurons. PRS-Jet Lag alleviates the effect
of this stress.
In order to optimize the recovery, exercise
the following guidelines:
1- Take PRS-Jet Lag before the trip.
2- Get enough rest before you start traveling.
3- Drink plenty of water during the flight so you do not get
dehydrated.
4- Do not drink alcohol before and during the flight.
5- When you arrive change your daily routine to the new schedule
as soon as possible.
6- Get outdoors in natural light as much as possible.
7- Plan for a light schedule for the first two days after
you arrive.
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